Tokito Oda will have an eye on becoming the first player to win four Roland Garros's wheelchair men's singles titles in a row since compatriot Shingo Kunieda achieved the feat between 2007 and 2010.
Yui Kamiji and Diede De Groot, meanwhile, both enter the event as five-time women's champions at Roland Garros.
Guy Sasson will target the Roland Garros quad title for the third straight year.